Neuroscience and Neuro-urology Research
Disorders of storage and voiding of urine in the bladder (these include overactive bladder, incontinence and other lower urinary tract symptoms (LUTS)) affect millions of people, and lack of a complete understanding of the mechanisms underlying LUT function hampers treatment.
Fundamental/ Basic (i.e., not-clinical) research conducted by our labs is aimed at elucidating the molecular and cellular basis for diseases of voiding dysfunction. We study the function and anatomy of (neurons in) the brain micturition control centers and the neural circuits, in relation to bladder control, both in healthy and in disease models.
Neuro-urology research: lower urinary tract symptoms (LUTS) are likely caused or exacerbated by dysfunction of neural circuits controlling bladder function. Despite some progress in our understanding of the cellular and synaptic circuits that control reflex and voluntary micturition, significant knowledge gaps remain. We aim to identify the etiology and unravel the underlying neural mechanisms of lost bladder-control as this often accompanies neurological disorders, and our ultimate goal is to provide mechanistic insight, for novel treatments to be developed for patients with these dysfunctions.
Center for Life Science building
Location: Our lab is located in the Center for Life Science, where many of our collaborators from the Departments of Neurology and Medicine at BIDMC are also located.
Beth Israel Deaconess Medical Center
Center for Life Science
3 Blackfan Circle, Boston, MA 02215